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Gurbuxani, Sandeep
One or more keywords matched the following properties of Gurbuxani, Sandeep
PropertyValue
keywords Hematologic Malignancies
keywords Mouse models of Hematologic Malignancies
overview As an attending hematopathologist I am involved in diagnostic work up and follow up after therapy of patients diagnosed with hematologic malignancies including AML, ALL, MDS and MDS/MPN. I am interested in understanding the pathogenesis of hematopoietic tumors and how specific events required for leukemic transformation can be targeted for therapy. In addition, as part of collaborative research projects I have been involved in the analyses of mice in models of normal and malignant hematopoiesis.
One or more keywords matched the following items that are connected to Gurbuxani, Sandeep
Item TypeName
Concept Models, Molecular
Concept Mice, Transgenic
Concept Models, Genetic
Concept Mice, Inbred BALB C
Concept Mice, Inbred C57BL
Concept Mice, Knockout
Concept Mice
Concept Hematologic Neoplasms
Concept Disease Models, Animal
Concept Mice, Mutant Strains
Concept Models, Biological
Academic Article Heat-shock protein 70 antagonizes apoptosis-inducing factor.
Academic Article Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways.
Academic Article HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation.
Academic Article Increased immunogenicity of colon cancer cells by selective depletion of cytochrome C.
Academic Article Heat shock proteins: endogenous modulators of apoptotic cell death.
Academic Article Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.
Academic Article Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome.
Academic Article Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells.
Academic Article MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia.
Academic Article FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis.
Academic Article E2A proteins promote development of lymphoid-primed multipotent progenitors.
Academic Article FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis.
Academic Article Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.
Academic Article Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Academic Article Overexpression of survivin initiates hematologic malignancies in vivo.
Academic Article Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells.
Academic Article Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.
Academic Article Differential requirements for survivin in hematopoietic cell development.
Academic Article AKT is a therapeutic target in myeloproliferative neoplasms.
Academic Article Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage.
Academic Article Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation.
Academic Article Overexpression and knockout of miR-126 both promote leukemogenesis.
Academic Article Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
Academic Article PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease.
Academic Article Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
Academic Article miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.
Academic Article Eradication of Acute Myeloid Leukemia with FLT3 Ligand-Targeted miR-150 Nanoparticles.
Academic Article Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis.
Academic Article Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis.
Academic Article Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS.
Academic Article Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks.
Academic Article LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.
Academic Article Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms.
Academic Article Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus.
Academic Article IL-13/IL-4 signaling contributes to fibrotic progression of the myeloproliferative neoplasms.
Academic Article Gata1s mutant mice display persistent defects in the erythroid lineage.
Academic Article Lymphatic coagulation and neutrophil extracellular traps in lung-draining lymph nodes of COVID-19 decedents.
Academic Article Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.
Academic Article The Times, They Are A-Changing: The Impact of Next-Generation Sequencing on Diagnosis, Classification, and Prognostication of Myeloid Malignancies With Focus on Myelodysplastic Syndrome, AML, and Germline Predisposition.
Academic Article Microbiota may affect the tumor type but not overall tumor development in two models of heritable cancer.
Search Criteria
  • Mouse
  • models
  • Hematologic Malignancies